A cough medicine will be tested as a new treatment for Parkinson’s disease
revealed on 01/16/2023 2:05 p.m
(credit score: Play/Freepik/rawpixel.com)
The drug Ambroxol, which is usually used in opposition to respiratory illnesses and to alleviate coughs, will be tested as a treatment for Parkinson’s. The research was led by researchers from University College London (UCL) in London and will consider the drug’s effectiveness in 330 individuals with a neurological disease that impacts motion, typically inflicting tremors and muscle stiffness.
“I’m delighted to guide this thrilling venture. This will be the primary time a drug focused particularly at a genetic explanation for Parkinson’s disease has reached this degree of testing and represents ten years of intensive and detailed work within the laboratory and in a proof-of-principle medical trial,” mentioned Prof. Anthony Shapira .
In 2009, a research discovered that Ambroxol elevated ranges of the enzyme glucocerebrosidase (GCase) in sufferers with the uncommon genetic disease Gaucher, who’re predisposed to growing Parkinson’s – though the hyperlink between the 2 illnesses is just not but absolutely understood by scientists.
“Once the Ambroxol trial begins, it will be considered one of solely six publicly registered part 3 trials of probably disease-modifying medicine in Parkinson’s worldwide,” mentioned Will Cooke, chief government of the charity. Cure Parkinson’s one of many funders of the analysis.
In 2020, the group of researchers tested the drug and noticed that Ambroxol was in a position to attain the sufferers’ brains and improve glucocerebrosidase ranges. The drug has additionally been discovered to be protected and nicely tolerated by individuals with Parkinson’s disease. The research is now transferring to part 3, which will be carried out on a giant scale. The analysis report can be accessed in full at this hyperlink.
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