health

understand the new wave of obesity drugs

When it involves weight reduction, the most conventional methodology of weight reduction is to realize a caloric deficit with a diverse and nutrient-dense weight loss plan, along with common train. Although the method appears easy, it isn’t simple to realize the anticipated outcome.

To assist overweight individuals who can not shed some pounds, it has been discovered that some drugs initially designed for diabetic sufferers can assist management starvation and scale back the quantity of meals eaten.

In Brazil, though there is no such thing as a particular indication for obesity, Ozempic (semaglutide) is the hottest choice. However, Mounjaro (tirzepatida) is awaiting permission from Anvisa to enter the market and has additionally proven good leads to scientific trials performed in overweight individuals.

Both are promising drugs each for bettering metabolic well being, selling weight reduction and decreasing blood sugar, and for stopping cardiovascular occasions, together with coronary heart assault and stroke.

But what’s the distinction between the two drugs? Endocrinologist Bruno Babetto, specialist in metabolism, explains what you want to find out about Ozempic and Mounjaro earlier than beginning any remedy. Explore:

1. What ought to you understand about obesity drugs?

“The most vital factor to remember of is that none of these are magic weight reduction instruments. Ozempic and Mounjaro are drugs that facilitate weight reduction and assist wholesome habits, however don’t scale back the numbers on the scale themselves,” explains the specialist. He states that these must be mixed with different ways to keep up metabolic well being, similar to dietary adjustments, train and sufficient sleep.

2. What are the variations between the two drugs?

Ozempic is a drug primarily designed to regulate kind 2 diabetes in adults and must be used together with weight loss plan and train. It has been out there in Brazil since 2018 and might solely be bought with a prescription. The drug is injected subcutaneously into the stomach, thigh, or higher arm, with weekly doses.

In apply, endocrinologists additionally prescribe semaglutide to deal with sufferers who’re chubby or overweight, a continual illness that opens the door to many different issues, similar to hypertension, diabetes, excessive ldl cholesterol and triglycerides, fatty liver, coronary heart illness, sleep apnea. and even most cancers.

The drug shouldn’t be but formally beneficial in Brazil for the remedy of obesity or weight reduction. But, in line with Babetto, in the United States, drugs with the energetic ingredient semaglutide are already permitted to be used by overweight or chubby people who find themselves not essentially diabetic.

The physician believes that the use for the similar functions could quickly be permitted in Brazil, as research present that the drug results in a discount of as much as 15% in the physique weight of chubby and overweight sufferers in a 12 months and a half.

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Mounjaro, with the energetic substance tirzepatide, can also be an injection pen designed to deal with kind 2 diabetes. It is a more recent drug and remains to be being analyzed by Anvisa, and isn’t permitted to be used in Brazil for any situation. The drug has additionally proven good outcomes for the remedy of obesity in different nations.

“When we eat, our our bodies launch two hormones: GIP and GLP-1. They inform the pancreas to launch insulin and induce a sense of satiety. These substances assist us digest meals correctly and hold blood sugar steady. And that is the place tirzepatide can assist, because it mimics what GIP and GLP-1 do naturally in the physique, contributing to emotions of satiety and subsequent weight reduction,” says Babetto.

Research has already proven that tirzepartida may cause weight reduction very near that obtained with bariatric surgical procedure, an invasive process that may carry dangers. For this motive, the risk of utilizing medicine as a substitute of the bariatric process is being explored.

3. Can I take advantage of Ozempic just for weight reduction?

You can, however by no means alone. The physician explains that though there is no such thing as a regulatory company approval to make use of it for weight reduction, Ozempic has proven constructive leads to research evaluating its effectiveness in overweight sufferers.

But the specialist factors out that earlier than utilizing the drug as an “unspecified” various for weight reduction, “the affected person should endure a strict evaluation and medical follow-up.” There is an understanding amongst endocrinologists that the drug must be prescribed to individuals with a physique mass index (BMI) between 28 and extreme obesity.

4. What are the contraindications?

Under no circumstances ought to the drug be administered with out medical supervision or indications, as doses and length of remedy are totally different for every affected person. Uncontrolled use can have critical penalties, similar to extreme allergic reactions to the parts and negative effects similar to diarrhea, vomiting, nausea and regaining misplaced weight.

It can also be contraindicated for pregnant girls, breastfeeding girls, individuals with liver or pancreatic issues, or with a household historical past of most cancers similar to thyroid.

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